Study highlights diagnostic accuracy of CT and MRI in detecting orbital involvement of IgG4-related disease

Both CT and MRI scans are useful for diagnosing orbital diseases, but their accuracy varies depending on the specific condition, according to a study.

The research involved 126 CT scans and 65 MRI scans from 144 patients, which were interpreted by 2 radiologists without prior clinical information. The diseases assessed included orbital infection, inflammation, and neoplasm, with inflammation further categorized into thyroid eye disease, non-specific orbital inflammation, IgG4-related disease, sarcoidosis, granulomatosis with polyangiitis, and Erdheim-Chester disease.

Radiologists demonstrated high accuracy in identifying conditions like granulomatosis with polyangiitis (98-99% balanced accuracy) and were effective at diagnosing thyroid eye disease (80-86% accuracy). However, performance was lower for conditions like sarcoidosis, with balanced accuracy between 48-50%. Overall, CT and MRI were valuable in evaluating orbital diseases, though accuracy varied depending on the condition.

Reference
Lee MJ, Verma R, Hamilton BE, et al. The utility of orbital imaging in the evaluation of orbital disease. PLoS One. 2024;19(8):e0308528. doi: 10.1371/journal.pone.0308528. PMID: 39213291; PMCID: PMC11364222.